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Background
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Product overview
Product Name
Brca1-Associated Protein
Code
E6565Hu
Assay type
Sandwich
Size
96 test
Sensitivity
10.09ng/L
Reactivity
Human
Detection range
10.09ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
BRAP;BRAP2;BRCA1-associated protein;IMP;Impedes mitogenic signal propagation;Renal carcinoma antigen NY-REN-63;RING finger protein 52;RING-type E3 ubiquitin transferase BRAP2
