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Background
Binds the telomeric double-stranded 5′-TTAGGG-3′ repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5′-TTAGGG-3′ repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Product overview
Product Name
Telomeric Repeat-Binding Factor 1
Code
E6257Hu
Assay type
Sandwich
Size
96 test
Sensitivity
9.63ng/L
Reactivity
Human
Detection range
9.63ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
NIMA-interacting protein 2;Telomeric protein Pin2/TRF1;Telomeric repeat-binding factor 1;TERF 1;TERF1;TTAGGG repeat-binding factor 1
