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Background
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Product overview
Product Name
Norrin
Code
E5788Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.056ng/mL
Reactivity
Human
Detection range
0.056ng/mL
Sample type
Serum, plasma, cell culture supernates
Synonyms
NDP;Norrie disease protein;Norrin;X-linked exudative vitreoretinopathy 2 protein
