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Background
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Product overview
Product Name
Nf-Kappa-B Inhibitor Alpha
Code
E5772Hu
Assay type
Sandwich
Size
96 test
Sensitivity
14.01ng/L
Reactivity
Human
Detection range
14.01ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
IkappaBalpha;I-kappa-B-alpha;IkB-alpha;Major histocompatibility complex enhancer-binding protein MAD3;NF-kappa-B inhibitor alpha;NFKBIA
