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Background
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Product overview
Product Name
Cytoplasmic Aconitate Hydratase
Code
E4338hu
Assay type
Sandwich
Size
96 test
Sensitivity
1.03ng/mL
Reactivity
Human
Detection range
1.03ng/mL
Sample type
Serum, plasma, cell culture supernates
Synonyms
ACO 1;ACO1;Aconitase;Citrate hydro-lyase;Cytoplasmic aconitate hydratase;Ferritin repressor protein;IRE-BP 1;Iron regulatory protein 1;Iron-responsive element-binding protein 1;IRP1
