Catalyzes the oxidation of sulfhydryl groups in Peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed: 17331072, PubMed: 18393449, PubMed: 23704371, PubMed: 30367560, PubMed: 23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed: 17331072, PubMed: 30367560, PubMed: 22801504, PubMed: 23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed: 23704371, PubMed: 30367560, PubMed: 23867277).
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