A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed: 21289075, PubMed: 12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH–hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed: 21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed: 21289075, PubMed: 12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed: 11695850, PubMed: 22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed: 11695850). Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.
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