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Background
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed: 27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).
Product overview
Product Name
Gremlin 1
Code
E2735Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.025ng/ml
Reactivity
Human
Detection range
0.025ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
Cell proliferation-inducing gene 2 protein;Cysteine knot superfamily 1, BMP antagonist 1;DAN domain family member 2;Down-regulated in Mos-transformed cells protein;GREM 1;GREM1;Gremlin-1;IHG-2;Increased in high glucose protein 2;
