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Background
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed: 27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed: 11909953).
