Photoreceptor required for image-forming vision at low light intensity (PubMed: 8107847, PubMed: 7846071). Required for photoreceptor cell viability after birth (PubMed: 2215617, PubMed: 12566452). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed: 8107847, PubMed: 28524165, PubMed: 26200343, PubMed: 28753425). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed: 28524165, PubMed: 26200343).
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