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Background
Induces cartilage and bone formation (PubMed: 3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed: 24362451).
Product overview
Product Name
Bone Morphogenetic Protein 2
Code
E1989Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.01ng/ml
Reactivity
Human
Detection range
0.01ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
BMP 2;BMP2;BMP-2;BMP-2A;Bone morphogenetic protein 2;Bone morphogenetic protein 2A
