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Background
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed: 28553959).
Product overview
Product Name
Pachytene Checkpoint Protein 2 Homolog
Code
E1743Hu
Assay type
Sandwich
Size
96 test
Sensitivity
5.91ng/L
Reactivity
Human
Detection range
5.91ng/L
Sample type
Serum, plasma, cell culture supernates
Synonyms
16E1-BP;HPV16 E1 protein-binding protein;Human papillomavirus type 16 E1 protein-binding protein;Pachytene checkpoint protein 2 homolog;Thyroid hormone receptor interactor 13;Thyroid receptor-interacting protein 13;TR-interacting protein 13;TRIP 13;TRIP13;TRIP-13
