In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed: 28803808). Besides it’s role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed: 11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed: 3352745, PubMed: 11004567). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed: 3352745, PubMed: 11004567).
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