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Background
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Product overview
Product Name
C-C Chemokine Receptor Type 4
Code
E0225Hu
Assay type
Sandwich
Size
96 test
Sensitivity
0.021ng/ml
Reactivity
Human
Detection range
0.021ng/ml
Sample type
Serum, plasma, cell culture supernates
Synonyms
C-C chemokine receptor type 4;C-C CKR-4;CC-CKR-4;CCR 4;CCR4;CCR-4;CD antigen CD194;K5-5
