Trichostatin A – A HDAC inhibitor
Datasheet (PDF) | Safety Data Sheets (MSDS)(PDF)
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Description
Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6- methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis.
Datasheet
Cat # +Size | 1606-1 |
---|---|
Size | 1 mg |
Alternate Name | TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
Appearance | White solid |
CAS # | 58880-19-6 |
Molecular Formula | C₁₇H₂₂N₂O₃ |
Molecular Weight | 302.4 |
Purity | ≥99% |
Solubility | DMSO (20 mg/ml) or EtOH (2 mg/ml) |
SMILES | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
InChi | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
InChi Key | RTKIYFITIVXBLE-QEQCGCAPSA-N |
PubChem CID | 444732 |
MDL Number | MFCD03848392 |
Handling | Protect from air and moisture |
Storage Conditions | -20°C |
Shipping Conditions | Gel Pack |
USAGE | For Research Use Only! Not For Use in Humans. |
FAQ
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CITATIONS
Chen, S. et. al. Histone Deacetylase (HDAC) Activity Is Critical for Embryonic Kidney Gene Expression, Growth, and Differentiation. J. Biol. Chem., Sep 2011; 286: 32775 - 32789.
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