KEY FEATURES:• Amine reactive Sulfo-NHS ester that crosslinks efficiently with primary amine-containing molecules• Has a maleimide functional group that can be utilized to react specifically with cysteines or sulfhydryl (-SH) groups• Water-soluble; can be used under physiologic conditions• Has a spacer arm length of 8.3 Å (9 atom)• Unlike other maleimide-activated antibodies, those made with Sulfo-SMCC crosslinkers are often more stable, due to the inductive stabilizing effects of the cyclohexyl ring moeityAPPLICATIONS:• Routinely used to prepare hapten-carrier protein and antibody-enzyme conjugates, such as HRP conjugation. • Wide range of uses for both small molecule reactions and large biomolecule applications.


SKU-Size2320-50 (Size: 50 mg)
2320-100 (Size: 100 mg)
2320-1000 (Size: 1000 mg)
2320-set (Size: 1 set (10 x 2 mg))
Alternate Name 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt
Appearance White to off-white solid
CAS # 92921-24-9
Molecular Formula C₁₆H₁₇N₂NaO₉S
Molecular Weight 436.37
Purity ≥90% by NMR
Solubility H₂O (>10 mg/ml)
SMILES C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)ON3C(=O)CC(C3=O)S(=O)(=O)[O-].[Na+]
InChi InChI=1S/C16H18N2O9S.Na/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26;/h5-6,9-11H,1-4,7-8H2,(H,24,25,26);/q;+1/p-1
PubChem CID 4618794
MDL Number MFCD00054978
Handling Protect from moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


After I reconstitute the powder in water at 5mg/ml, how long can it be stored?
Reconstituted product can be stored at 4˚C protected from light for short term for a week. However, for long term storage we recommend storing the reconstituted product at -20˚C, protected from light.

Could you recommend storage conditions for powder and reconstituted powder?
Always protect the powder from light and moisture. Please allow the powder to come to RT before opening to reduce condensation inside the vial. Powder can be stored at 4˚C for short term and -20˚C for long term storage at -20˚C up to a year. Please keep it protected from moisture and light.
Reconstituted Solution - Only reconstitute what is necessary and any remaining can be stored at -20˚C. Reconstituted Solution should be aliquoted and avoid multiple freeze/thaw cycles. Fresh solution is recommended.

Ana C. Laly. The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction. Sci Adv. Jan 2021. PMC7840118.

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