Staurosporine – A protein kinase inhibitor
Datasheet (PDF) | Safety Data Sheets (MSDS)(PDF)
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Description
Potent inhibitor of protein kinase C and most other kinases, including tyrosine kinases. Inhibits topoisomerase II directly by blocking transfer of phosphodiester bonds from DNA to active site tyrosine. Induces apoptosis in CHO cells at 1 µM.
Datasheet
| Cat # +Size | 1048-01 (Size: 100 µg)
1048-1 (Size: 1 mg) |
| Alternate Name | Antibiotic AM-2282 |
| Appearance | Pale yellow solid |
| CAS # | 62996-74-1 |
| Molecular Formula | C₂₈H₂₆N₄O₃ |
| Molecular Weight | 466.53 |
| Purity | >99% by TLC |
| Solubility | DMSO ( 25 mg/ml) |
| SMILES | CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC |
| InChi | InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1 |
| InChi Key | HKSZLNNOFSGOKW-HMWZOHBLSA-N|
| PubChem CID | 451705 |
| MDL Number | MFCD00077402 |
| Handling | Protect from light and moisture |
| Storage Conditions | 4°C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
FAQ
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CITATIONS
Ellen Brenner, Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun., Mar. 2020; 32165639.
Carles Solà-Riera, Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells. Sci Rep., Jan. 2019; 30696898.
Debnath et al., Hsp90 Inhibitors as New Leads To Target Parasitic Diarrheal Diseases. Antimicrob. Agents Chemother., Jul 2014; 58: 4138 - 4144.
Lin K-R et al. (2007) J. Biol. Chem. 282: 21962-21972.
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