G418 Sulfate – An antibiotic and a selection agent


G418 Sulfate – An antibiotic and a selection agent


Datasheet (PDF)   |   Safety Data Sheets (MSDS)(PDF)

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Catalog# 1557

Size: 1 g


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Description




Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.

WARNING: This product can expose you to chemicals including G418 sulfate, which is [are] known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.


Datasheet




Cat # +Size 1557-1G ( Size: 1 g )
1557-5G ( Size: 5 g )
1557-25G ( Size: 25 g )
Alternate NameAntibiotic G418, G418
Appearance White to off-white solid
CAS # 108321-42-2
Molecular Formula C₂₀H₄₀N₄O₁₀. 2 H₂SO₄
Molecular Weight 692.71
Purity>720 U/mg (potency)
SolubilityH₂O (50 mg/ml)
SMILESCC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
InChi InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)
InChi KeyUHEPSJJJMTWUCP-UHFFFAOYSA-N
PubChem CID 16760463
MDL NumberMFCD00058314
Handling Protect from light and moisture
Storage Conditions-20°C
Shipping ConditionsGel Pack
USAGE For Research Use Only! Not For Use in Humans.




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CITATIONS

Lehman et al., Activation of the Retinoid X Receptor Modulates Angiotensin II-Induced Smooth Muscle Gene Expression and Inflammation in Vascular Smooth Muscle Cells. Mol. Pharmacol., Oct 2014; 86: 570 - 579.

Tian et al., The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity. J. Biol. Chem., Feb 2014; 289: 3339 - 3351.










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