Brefeldin A – Disruptor of Golgi apparatus
Datasheet (PDF) | Safety Data Sheets (MSDS)(PDF)
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Description
Brefeldin A has been shown to induce apoptosis in human tumor cells through caspase activation. It has also been shown to block translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.
Datasheet
Cat # +Size | 1560-5 ( Size: 5 mg ) 1560-50 ( Size: 50 mg ) |
Alternate Name | Ascotoxin, BFA, Cyanein, Decumbin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone |
Appearance | White solid |
CAS # | 20350-15-6 |
Molecular Formula | C₁₆H₂₄O₄ |
Molecular Weight | 280.36/td> |
Purity | ≥99% |
Solubility | DMSO or EtOH (10 mg/ml) |
SMILES | CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O |
InChi | InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3 |
InChi Key | KQNZDYYTLMIZCT-UHFFFAOYSA-N |
PubChem CID | 2430 |
MDL Number | MFCD12913297 |
Handling | Protect from light and moisture |
Storage Conditions | -20°C |
Shipping Conditions | RT |
USAGE | For Research Use Only! Not For Use in Humans. |
FAQ
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CITATIONS
Andrew S. Nelson, Oral therapy with colonization factor antigen I prevents development of type 1 diabetes in Non-obese Diabetic mice. Sci Rep., Apr. 2020; 32273533.
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