ProSci-Inc’s RIP3/RIPK3 Antibody – over 100 citations!

ProSci-Inc’s RIP3/RIPK3 antibody (Cat. No. 2283) is widely cited with as many as 171 citations on the antibody citation tracker CiteAb and 165 citations on Bioz. The reliability of our antibody has contributed to its popularity, finding its way into studies published in many top journals, including Nature (2021, 2012, 2011), Cell (2020, 2012, 2009), Science Immunology (2022), Nature Immunology (2014), and Nature Medicine (2014), etc. Crucially, our antibody has been involved in many studies relating to the development of therapeutics to combat. Crucially, our antibody has been involved in many studies relating to the development of therapeutics to combat the coronavirus and COVID-19.

Death of a Cell

RIPK3 promotes NLRP3 inflammasome activation and the necroptosis cell death pathway. An important contributor to the body’s response to microbial infections, RIPK3 is involved in the necroptosis and apoptosis of cells, as well as the release of damage-associated molecular patterns (DAMPs) that activate the body’s innate immune responses.  With the recent emergence of novel viruses such as SARS-CoV-2 and surges of known viruses such as influenza, MPOX, and RSV, RIPK3 has become a top target for research and therapeutics, but recent studies have shown it to be a viable target for several inflammatory diseases, degenerative diseases, and even cancer.

ProSci’s RIP3/RIPK3 Antibody Citations

ProSci’s RIP3/RIPK3 antibody (Cat. No. 2283) has been a key player in discovering the protein’s many roles and will continue to provide quality and reliability to researchers everywhere. Below are several articles showcasing the efficacy of using ProSci antibodies in your studies:

  1. Karki R, Lee S, Mall R, et al. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection. Sci Immunol. 2022;7(74):eabo6294. doi:10.1126/sciimmunol.abo6294
  2. Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021;597(7876):415-419. doi:10.1038/s41586-021-03875-8
  3. Zhang T, Yin C, Boyd DF, et al. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Cell. 2020;180(6):1115-1129.e13. doi:10.1016/j.cell.2020.02.050
  4. Zheng M, Karki R, Vogel P, Kanneganti TD. Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Cell. 2020;181(3):674-687.e13. doi:10.1016/j.cell.2020.03.040

The ProSci catalog includes over 30,000 research-grade antibodies as well as ProSci custom antibody specialists to help researchers design and develop antibodies for their unique assays and experiments.  For more information about our RIP3 antibody, visit its’ product page or see all products to view our full catalog of antibodies.

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* – Has been cited
** – Over 50 citations
*** – Over 100 citations


Dai, W., Cheng, J., Leng, X., Hu, X., & Ao, Y. (2021). The potential role of necroptosis in clinical diseases. International Journal of Molecular Medicine, 47, 89.