Human Mucin-4, MUC4 ELISA Kit
Product Summary
• Size: 48T,96T
• Sensitivity: 5.48pg/ml
• Detection range: 10-3000pg/ml
• Reactive with: Human
Product Details
Product Specifications |
|
---|---|
Full Product Name: |
Mucin-4 |
Catalog No.: |
BL1940EH |
Size: |
48T,96T |
Detaction Range: |
10-3000pg/ml |
Sensitivity: |
5.48pg/ml |
Sample Type: |
Serum, plasma, cell culture supernates |
Assay Type: |
Sandwich |
Species: |
Human |
Storage: |
2-8ºC |
Assay Time: |
1h 30m |
Background: |
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. |
UniProt: |
|
MASS(Da): |
231,518 |
GeneID: |
4585 |
Synonyms: |
Ascites sialoglycoprotein;Ascites sialoglycoprotein 1;Ascites sialoglycoprotein 2;ASGP;ASGP-1;ASGP-2;MUC 4;MUC4;MUC-4;Mucin-4;Mucin-4 alpha chain;Mucin-4 beta chain;Pancreatic adenocarcinoma mucin;Testis mucin;Tracheobronchial mucin |
Gene Names: |
MUC4 |
Research Area: |
Signal Transduction |
Target Protein: |
MUC4 |
*For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Components
Components | Quantity |
Pre-coated ELISA Plate | 12 * 8 well strips x1 |
Standard solution | 0.5ml x1 |
Standard diluent | 3ml x1 |
Streptavidin-HRP | 6ml x1 |
Stop solution | 6ml x1 |
Substrate solution A | 6ml x1 |
Substrate solution B | 6ml x1 |
Wash buffer concentrate | (25x) 20ml x1 |
Biotinylated antibody | 1ml x1 |
Documents
Technical Guide
Technical Guide: Human Mucin-4, MUC4 ELISA KitSafety Data Sheets (SDS)
MSDS: Human Mucin-4, MUC4 ELISA KitReferences
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