Full Product Name:

Interleukin 10

Catalog No.:

BL0043ECA

Size:

48T,96T

Detaction Range:

20-4000ng/L

Sensitivity:

10.51ng/L

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Cat

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).

UniProt:

P55029

MASS（Da）:

20,575

GeneID:

493683

Synonyms:

CSIF;Cytokine synthesis inhibitory factor;IL-10;Interleukin-10

Gene Names:

IL10

Research Area:

Immunology

Target Protein:

IL-10