Full Product Name:

Fibroblast Growth Factor 1

Catalog No.:

BL2104E

Size:

48T,96T

Detaction Range:

2-700ng/L

Sensitivity:

0.96ng/L

Sample Type:

Serum, plasma, cell culture supernates

Assay Type:

Sandwich

Species:

Bovine

Storage:

2-8ºC

Assay Time:

1h 30m

Background:

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis (By similarity).

UniProt:

P03968

MASS（Da）:

17,493

GeneID:

281160

Synonyms:

Acidic eye-derived growth factor II;Acidic fibroblast growth factor;aFGF;ECGF;EDGF II;Endothelial cell growth factor;Endothelial cell growth factor alpha;Endothelial cell growth factor beta;FGF 1;FGF1;FGF-1;Fibroblast growth factor 1;HBGF-1;Heparin-binding growth factor 1;Prostatropin

Gene Names:

FGF1

Research Area:

Cardiovascular; Signal Transduction; Cancer

Target Protein:

FGF1