PRODUCT NAME

TIMP-1 (4C2) Monoclonal Antibody, HRP Conjugated

CONJUGATION

HRP

HOST

Mouse

SOURCE

Recombinant human TIMP-1

IMMUNOGEN RANGE

CLONALITY

Monoclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein G.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin.

STORAGE CONDITION

Store at 4°C for 12 months.

GENE ID

7076

SUBCELLULAR LOCATION

SYNONYMS

Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Tissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.

BACKGROUND

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq].

APPLICATION DILUTION

WB(1:300-1000), IHC-P(1:200-400)