RNF31 Polyclonal Antibody, FITC Conjugated
- Size: 100ul
- Application: IF(IHC-P)
- Reactivity: Human, Mouse, Rat
- Predicted Reactivity:
-
Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
RNF31 Polyclonal Antibody, FITC Conjugated |
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CONJUGATION |
FITC |
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HOST |
Rabbit |
| SOURCE |
KLH conjugated synthetic peptide derived from human RNF31 |
| IMMUNOGEN RANGE |
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| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at 4°C for 12 months. |
TARGET |
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| GENE ID |
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| SUBCELLULAR LOCATION |
Cytoplasm |
| SYNONYMS |
HOIP; ZIBRA; E3 ubiquitin-protein ligase RNF31; HOIL-1-interacting protein; RING finger protein 31; Zinc in-between-RING-finger ubiquitin-associated domain protein; RNF31 |
| BACKGROUND |
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. |
| APPLICATION DILUTION |
IF(IHC-P)(1:50-200) |