phospho-IRS1 (Tyr632) Polyclonal Antibody, Biotin Conjugated
- Size: 100ul
- Application: IHC-P
- Reactivity: Human, Mouse, Rat, Bovine, Dog, Pig, Sheep, Rabbit
- Predicted Reactivity:
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Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
phospho-IRS1 (Tyr632) Polyclonal Antibody, Biotin Conjugated |
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CONJUGATION |
Biotin |
|
HOST |
Rabbit |
| SOURCE |
KLH conjugated Synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Tyr632 |
| IMMUNOGEN RANGE |
|
| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at -20°C for 12 months. |
TARGET |
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| GENE ID |
|
| SUBCELLULAR LOCATION |
Cell membrane |
| SYNONYMS |
IRS1 (phospho Tyr632); IRS1 (phospho Y632); p-IRS1 (phospho Y632); HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS 1; IRS-1; IRS1; IRS1_HUMAN; OTTHUMP00000164234. |
| BACKGROUND |
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed. |
| APPLICATION DILUTION |
IHC-P(1:200-400) |
