phospho-IRS1 (Tyr632) Polyclonal Antibody, ALEXA FLUOR¨ 750 Conjugated


phospho-IRS1 (Tyr632) Polyclonal Antibody, ALEXA FLUOR¨ 750 Conjugated

  • Size: 100ul
  • Application: FCM
  • Reactivity: Human, Mouse, Rat, Bovine, Dog, Pig, Sheep, Rabbit
  • Predicted Reactivity:

  • Datasheet      Tech Support


Catalog# bs-8707R-A750

Size:100ul Datasheet


 SizePrice
 100ul ₹ 52662

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PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

phospho-IRS1 (Tyr632) Polyclonal Antibody, ALEXA FLUOR¨ 750 Conjugated

CONJUGATION

ALEXA FLUOR¨ 750

HOST

Rabbit

SOURCE

KLH conjugated Synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Tyr632

IMMUNOGEN RANGE

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.


TARGET

GENE ID

3667

SUBCELLULAR LOCATION

Cell membrane

SYNONYMS

IRS1 (phospho Tyr632); IRS1 (phospho Y632); p-IRS1 (phospho Y632); HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS 1; IRS-1; IRS1; IRS1_HUMAN; OTTHUMP00000164234.

BACKGROUND

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

APPLICATION DILUTION

FCM(1:20-100)












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