MMS19 Polyclonal Antibody, Cy7 Conjugated
- Size: 100ul
- Application: IF(IHC-P), IF(IHC-F), IF(ICC)
- Reactivity: Human, Mouse
- Predicted Reactivity: Rat, Dog, Pig, Horse, Rabbit
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Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
MMS19 Polyclonal Antibody, Cy7 Conjugated |
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CONJUGATION |
Cy7 |
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HOST |
Rabbit |
| SOURCE |
KLH conjugated synthetic peptide derived from human MMS 19 |
| IMMUNOGEN RANGE |
851-950/1030 |
| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at 4°C for 12 months. |
TARGET |
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| GENE ID |
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| SUBCELLULAR LOCATION |
Nucleus |
| SYNONYMS |
MET18; MMS19L; hMMS19; MMS19 nucleotide excision repair protein homolog; MET18 homolog; MMS19-like protein; MMS19 |
| BACKGROUND |
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. |
| APPLICATION DILUTION |
IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200) |
