MMS19 Polyclonal Antibody, ALEXA FLUOR¨ 680 Conjugated


MMS19 Polyclonal Antibody, ALEXA FLUOR¨ 680 Conjugated

  • Size: 100ul
  • Application: IF(IHC-P), IF(IHC-F), IF(ICC)
  • Reactivity: Human, Mouse
  • Predicted Reactivity: Rat, Dog, Pig, Horse, Rabbit

  • Datasheet      Tech Support


Catalog# bs-8671R-A680

Size:100ul Datasheet


 SizePrice
 100ul ₹ 44220

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PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

MMS19 Polyclonal Antibody, ALEXA FLUOR¨ 680 Conjugated

CONJUGATION

ALEXA FLUOR¨ 680

HOST

Rabbit

SOURCE

KLH conjugated synthetic peptide derived from human MMS 19

IMMUNOGEN RANGE

851-950/1030

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.


TARGET

GENE ID

64210

SUBCELLULAR LOCATION

Nucleus

SYNONYMS

MET18; MMS19L; hMMS19; MMS19 nucleotide excision repair protein homolog; MET18 homolog; MMS19-like protein; MMS19

BACKGROUND

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

APPLICATION DILUTION

IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)












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