MBD2 Monoclonal Antibody


MBD2 Monoclonal Antibody



Catalog# bsm-51671M

Size:100ul Datasheet


 SizePrice
 100ul ₹ 50828

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PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

MBD2 Monoclonal Antibody

CONJUGATION

Unconjugated

HOST

Mouse

SOURCE

Recombinant human MBD2 between 10-228 amino acids.

IMMUNOGEN RANGE

CLONALITY

Monoclonal

ISOTYPE

CONCENTRATION

1ug/ul

PURIFICATION

STORAGE BUFFER

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

STORAGE CONDITION

Shipped at 4_. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.


TARGET

GENE ID

8932

SUBCELLULAR LOCATION

Nucleus

SYNONYMS

Demethylase; DMTase; MBD 2; MBD2_HUMAN; MBD2a; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; Methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2; NY CO 41.

BACKGROUND

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

APPLICATION DILUTION

WB(1:300-1000), IHC-P(1:200-400)












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