MBD2 Monoclonal Antibody, Biotin Conjugated
- Size: 100ul
- Application: WB, IHC-P
- Reactivity:
- Predicted Reactivity: Human
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Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
MBD2 Monoclonal Antibody, Biotin Conjugated |
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CONJUGATION |
Biotin |
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HOST |
Mouse |
| SOURCE |
Recombinant human MBD2 between 10-228 amino acids. |
| IMMUNOGEN RANGE |
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| CLONALITY |
Monoclonal |
| ISOTYPE |
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| CONCENTRATION |
1ug/ul |
| PURIFICATION |
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| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at -20°C for 12 months. |
TARGET |
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| GENE ID |
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| SUBCELLULAR LOCATION |
Nucleus |
| SYNONYMS |
Demethylase; DMTase; MBD 2; MBD2_HUMAN; MBD2a; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; Methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2; NY CO 41. |
| BACKGROUND |
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. |
| APPLICATION DILUTION |
WB(1:300-1000), IHC-P(1:200-400) |