LATS1 (Thr1079) Polyclonal Antibody


LATS1 (Thr1079) Polyclonal Antibody

  • Size: 100ul
  • Application: WB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC)
  • Reactivity: Human, Mouse
  • Predicted Reactivity: Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit

  • Datasheet      Tech Support


Catalog# bs-7913R

Size:100ul Datasheet


 SizePrice
 100ul ₹ 40479

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IMAGES






PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

LATS1 (Thr1079) Polyclonal Antibody

CONJUGATION

Unconjugated

HOST

Rabbit

SOURCE

KLH conjugated synthetic phosphopeptide derived from human LATS1 around the phosphorylation site of Thr1079

IMMUNOGEN RANGE

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at -20°C for 12 months..


TARGET

GENE ID

9113

SUBCELLULAR LOCATION

Cytoplasm

SYNONYMS

wts; WARTS; Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts; LATS1

BACKGROUND

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

APPLICATION DILUTION

WB(1:300-1000), ELISA(1:500-1000), IHC-P(1:200-400), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)












CITATION






  • Gao R et al. PM2.5-associatedÊnitro-PAHÊexposureÊpromotesÊtumorÊcellÊmetastasisÊthroughÊHippo-YAPmediatedÊtranscriptionalÊregulation. Sci Total Environ. 2019 Aug 15;678:611-617. , Sci Total Environ.
    WB | Human
  • Konishi,et al.Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury.(2018) American Journal of Physiology. Gastrointestinal and Liver Physiology. 314:G471-G482., American Journal of Physiology. Gastrointestinal and Liver Physiology
    WB | Mouse
  • Fatah,et al.Reduced Proximal Tubular Expression of Megalin and Neonatal Fc Receptor in Proteinuria: The Role of Matrix Metalloproteinases.(2018) . :.,
    WB, IHC-P | Human


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