LATS1 (Thr1079) Polyclonal Antibody, ALEXA FLUOR¨ 350 Conjugated
- Size: 100ul
- Application: IF(IHC-P), IF(IHC-F), IF(ICC)
- Reactivity: Human, Mouse
- Predicted Reactivity: Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
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Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
LATS1 (Thr1079) Polyclonal Antibody, ALEXA FLUOR¨ 350 Conjugated |
CONJUGATION |
ALEXA FLUOR¨ 350 |
HOST |
Rabbit |
SOURCE |
KLH conjugated synthetic phosphopeptide derived from human LATS1 around the phosphorylation site of Thr1079 |
IMMUNOGEN RANGE |
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CLONALITY |
Polyclonal |
ISOTYPE |
IgG |
CONCENTRATION |
1ug/ul |
PURIFICATION |
Purified by Protein A. |
STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
STORAGE CONDITION |
Store at 4°C for 12 months. |
TARGET |
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GENE ID |
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SUBCELLULAR LOCATION |
Cytoplasm |
SYNONYMS |
wts; WARTS; Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts; LATS1 |
BACKGROUND |
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. |
APPLICATION DILUTION |
IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200) |