KDM5B Polyclonal Antibody, FITC Conjugated


KDM5B Polyclonal Antibody, FITC Conjugated

  • Size: 100ul
  • Application: FCM, IF(IHC-P), IF(IHC-F), IF(ICC)
  • Reactivity: Human, Rat
  • Predicted Reactivity: Mouse, Dog, Cow, Pig, Horse, Chicken, Guinea Pig

  • Datasheet      Tech Support


Catalog# bs-6139R-FITC

Size:100ul Datasheet


 SizePrice
 100ul ₹ 44220

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PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

KDM5B Polyclonal Antibody, FITC Conjugated

CONJUGATION

FITC

HOST

Rabbit

SOURCE

KLH conjugated synthetic peptide derived from human KDM5B/Jarid1B

IMMUNOGEN RANGE

65-165/1544

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.


TARGET

GENE ID

10765

SUBCELLULAR LOCATION

Nucleus

SYNONYMS

CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBBP2H1A; Lysine-specific demethylase 5B; Cancer/testis antigen 31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1; KDM5B; RBBP2H1

BACKGROUND

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

APPLICATION DILUTION

FCM(1:20-100), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)












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