KDM5B Polyclonal Antibody, Cy5.5 Conjugated
- Size: 100ul
- Application: FCM, IF(IHC-P), IF(IHC-F), IF(ICC)
- Reactivity: Human, Rat
- Predicted Reactivity: Mouse, Dog, Cow, Pig, Horse, Chicken, Guinea Pig
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Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
KDM5B Polyclonal Antibody, Cy5.5 Conjugated |
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CONJUGATION |
Cy5.5 |
|
HOST |
Rabbit |
| SOURCE |
KLH conjugated synthetic peptide derived from human KDM5B/Jarid1B |
| IMMUNOGEN RANGE |
65-165/1544 |
| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at 4°C for 12 months. |
TARGET |
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| GENE ID |
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| SUBCELLULAR LOCATION |
Nucleus |
| SYNONYMS |
CT31; PLU1; PUT1; PLU-1; JARID1B; PPP1R98; RBBP2H1A; Lysine-specific demethylase 5B; Cancer/testis antigen 31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1; KDM5B; RBBP2H1 |
| BACKGROUND |
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). |
| APPLICATION DILUTION |
FCM(1:20-100), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200) |
