hHBrk1 Polyclonal Antibody, FITC Conjugated


hHBrk1 Polyclonal Antibody, FITC Conjugated

  • Size: 100ul
  • Application: IF(IHC-P), IF(IHC-F), IF(ICC)
  • Reactivity:
  • Predicted Reactivity: Human, Mouse, Rat, Cow, Pig

  • Datasheet      Tech Support


Catalog# bs-5124R-FITC

Size:100ul Datasheet


 SizePrice
 100ul ₹ 44220

Contact Us





PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

hHBrk1 Polyclonal Antibody, FITC Conjugated

CONJUGATION

FITC

HOST

Rabbit

SOURCE

KLH conjugated synthetic peptide derived from human hHBrk1

IMMUNOGEN RANGE

31-75/75

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.


TARGET

GENE ID

55845

SUBCELLULAR LOCATION

Cytoplasm

SYNONYMS

Brk1-like; C3orf10 chromosome 3 open reading frame 10; C3ORF10 GENE; Chromosome 3 open reading frame 10; hHBrk1; HSPC300; MDS027; Probable protein BRICK1; BRK1_HUMAN.

BACKGROUND

HSPC300 (hematopoietic stem cell protein 300) is also known as probable protein BRICK1 or C3orf10 (chromosome 3 open reading frame 10) and is a 75 amino acid protein that is expressed as two isoforms and localizes to both the cytoplasm and the cytoskeleton. HSPC300 is thought to regulate cytoskeletal organization and Actin polymerization. Free HSPC300 exists as homotrimers prior to its incorporation into the WAVE complex. The WAVE complex includes five proteins, one of which is HSPC300, that regulate the ARC (Arp2/3 complex) which is responsible for Actin nucleation and is Rac 1-dependent. Because HSPC300 is a highly conserved subunit of the WAVE complex across many species, it is thought to have the same or similar functions in many different organisms. In Drosophila, the WAVE/ARC pathway may affect the development of the nervous system. HSPC300 is thought to localize to axons of the central nervous system of Drosophila embryos and thus may also be involved in axonogenesis. In addition, HSPC300 is thought to be necessary for synaptic morphogenesis by motoneurons. In mice, the knockout of the WAVE complex leads to learning and memory defects, and it is therefore hypothesized that HSPC300 may also be involved in cognitive functions. Genetic depletion of HSPC300 results in cytoskeletal abnormalities and prevents cytokinesis of cells, suggesting that decreased levels of HSPC300 may be associated with tumor suppression.

APPLICATION DILUTION

IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)












CITATION







Have you cited this product in a publication?
Let us know so we can reference it here.

Contact Us










We're here to help


Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.


Contact Tech Support







High Quality Guaranteed Product


Our products such as Elisa, Antibodies, Proteins, Peptides are covered by Biolinkk quality warranty and will work as described in datasheet, a free replacement or money back is guaranteed if does not perform according to datasheet.


Learn More