PRODUCT NAME

HECA Polyclonal Antibody, FITC Conjugated

CONJUGATION

FITC

HOST

Rabbit

SOURCE

KLH conjugated synthetic peptide derived from human HECA

IMMUNOGEN RANGE

260-310/543

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.

GENE ID

51696

SUBCELLULAR LOCATION

SYNONYMS

HDCL; Gm869; HDC; HDC_HUMAN; Headcase homolog Drosophila; Headcase protein homolog; HECA; hHDC.

BACKGROUND

HECA, also known as headcase homolog, HDC, HDCL or HHDC, is a 543 amino acid mammalian homolog of the Drosophila headcase protein, a highly basic, cytplasmic peptide that plays a role in mitotic re-entry during adult morphogenesis. Expressed in a variety of tissues with highest expression in thymus, spleen and heart, HECA is thought to play a role in the development of epithelial tube networks in lung tissue and may also be involved in the pathogenesis of lung cancer. The gene encoding HECA maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

APPLICATION DILUTION

IF(IHC-P)(1:50-200)