Frizzled 7 Polyclonal Antibody, Cy3 Conjugated
- Size: 100ul
- Application: FCM, IF(IHC-P), IF(IHC-F), IF(ICC)
- Reactivity: Human, Mouse, Rat
- Predicted Reactivity: Dog, Cow, Pig, Chicken, Guinea Pig
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Datasheet
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
Frizzled 7 Polyclonal Antibody, Cy3 Conjugated |
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CONJUGATION |
Cy3 |
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HOST |
Rabbit |
| SOURCE |
KLH conjugated synthetic peptide derived from human Frizzled 7 |
| IMMUNOGEN RANGE |
501-574/574 |
| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at 4°C for 12 months. |
TARGET |
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| GENE ID |
|
| SUBCELLULAR LOCATION |
Cell membrane |
| SYNONYMS |
FzE3; Frizzled-7; Fz-7; hFz7; FZD7 |
| BACKGROUND |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| APPLICATION DILUTION |
FCM(1:20-100), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200) |