ERBB2 (CG8) Monoclonal Antibody
- Size: 100ul
- Application: WB
- Reactivity: Human
- Predicted Reactivity:
-
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IMAGES
PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
ERBB2 (CG8) Monoclonal Antibody |
CONJUGATION |
Unconjugated |
HOST |
Rabbit |
SOURCE |
Recombinant human HER2 extracellular domain |
IMMUNOGEN RANGE |
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CLONALITY |
Monoclonal |
ISOTYPE |
IgG |
CONCENTRATION |
1ug/ul |
PURIFICATION |
Purified by Protein A. |
STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
STORAGE CONDITION |
Store for 1 year at -20°C from date of shipment. Store for 1 year at -20°C from date of shipment. |
TARGET |
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GENE ID |
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SUBCELLULAR LOCATION |
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SYNONYMS |
Receptor tyrosine-protein kinase erbB-2; ERBB2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD340; NGL |
BACKGROUND |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
APPLICATION DILUTION |
WB(1:300-1000) |