PRODUCT NAME

DHX32 Polyclonal Antibody, ALEXA FLUOR¨ 680 Conjugated

CONJUGATION

ALEXA FLUOR¨ 680

HOST

Rabbit

SOURCE

KLH conjugated synthetic peptide derived from human DHX32

IMMUNOGEN RANGE

561-660/743

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.

GENE ID

SUBCELLULAR LOCATION

Cytoplasm, Nucleus

SYNONYMS

Ddx32; DEAD/H Asp-Glu-Ala-Asp/His box polypeptide 32; DEAD/H box 32; DEAD/H helicase like protein 1; DEAH Asp-Glu-Ala-His box polypeptide 32; DEAH box protein 32; DHLP1; DHX32; Helicase DDX32; HuDDX32; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DHX32_HUMAN.

BACKGROUND

DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX32 is a 743 amino acid nuclear protein that localizes to the mitochondria and is a member of the DEAD box helicase family. Expressed in various tissues, DDX32 is up-regulated by ionomycin in T lymphocytes and down-regulated in acute lymphoblastic leukemia. Considered a novel RNA helicase, DDX32 may play an important role in the development of colorectal cancer and may be involved in regulating T-cell response to certain apoptotic stimuli.

APPLICATION DILUTION

IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)