PRODUCT NAME

DAXX (Ser495) Polyclonal Antibody, ALEXA FLUOR¨ 555 Conjugated

CONJUGATION

ALEXA FLUOR¨ 555

HOST

Rabbit

SOURCE

KLH conjugated synthetic phosphopeptide derived from human DAXX around the phosphorylation site of Ser495

IMMUNOGEN RANGE

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.

GENE ID

1616

SUBCELLULAR LOCATION

Cytoplasm, Nucleus

SYNONYMS

DAP6; EAP1; BING2; Death domain-associated protein 6; Daxx; hDaxx; ETS1-associated protein 1; Fas death domain-associated protein

BACKGROUND

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

APPLICATION DILUTION

IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)