BRCA1(Ser988) Polyclonal Antibody, ALEXA FLUOR¨ 647 Conjugated


BRCA1(Ser988) Polyclonal Antibody, ALEXA FLUOR¨ 647 Conjugated

  • Size: 100ul
  • Application: IF(IHC-P), IF(IHC-F), IF(ICC)
  • Reactivity: Human
  • Predicted Reactivity:

  • Datasheet      Tech Support


Catalog# bs-8444R-A647

Size:100ul Datasheet


 SizePrice
 100ul ₹ 52662

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PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

BRCA1(Ser988) Polyclonal Antibody, ALEXA FLUOR¨ 647 Conjugated

CONJUGATION

ALEXA FLUOR¨ 647

HOST

Rabbit

SOURCE

KLH conjugated synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser998

IMMUNOGEN RANGE

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.


TARGET

GENE ID

672

SUBCELLULAR LOCATION

Cytoplasm

SYNONYMS

BRCA1 Ser988; BRCA1 phospho S988; p-BRCA1 phospho S988; BRCA 1; BRCA1; BRCA1/BRCA2 containing complex subunit 1; BRCA1/BRCA2-containing complex, subunit 1; BRCA1_HUMAN; BRCAI; BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast and ovarian cancer susceptibility protein 1; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; RNF53; BAP1.

BACKGROUND

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].

APPLICATION DILUTION

IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)












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