ARP4 Polyclonal Antibody
- Size: 100ul
- Application: WB, ELISA, IHC-P
- Reactivity: Mouse, Rat
- Predicted Reactivity: Human, Dog, Cow, Pig, Rabbit
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Datasheet
Tech Support
IMAGES
Formalin-fixed and paraffin embedded rat liver labeled with Anti-ARP4 Polyclonal Antibody, Unconjugated (bs-5027R) at 1:200 followed by conjugation to the secondary antibody
PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
ARP4 Polyclonal Antibody |
|
CONJUGATION |
Unconjugated |
|
HOST |
Rabbit |
| SOURCE |
KLH conjugated synthetic peptide derived from mouse ARP4 |
| IMMUNOGEN RANGE |
331-410/410 |
| CLONALITY |
Polyclonal |
| ISOTYPE |
IgG |
| CONCENTRATION |
1ug/ul |
| PURIFICATION |
Purified by Protein A. |
| STORAGE BUFFER |
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
| STORAGE CONDITION |
Store at -20°C for 12 months.. |
TARGET |
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|---|---|
| GENE ID |
|
| SUBCELLULAR LOCATION |
Secreted, Extracellular matrix |
| SYNONYMS |
Arp4; Bk89; Fiaf; Ng27; Pgar; Hfarp; Pgarg; Pp1158; Angiopoietin-related protein 4; 425O18-1; Angiopoietin-like protein 4; Fasting-induced adipose factor; Hepatic fibrinogen/angiopoietin-related protein; Secreted protein Bk89; Angptl4; Farp |
| BACKGROUND |
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. |
| APPLICATION DILUTION |
WB(1:300-1000), ELISA(1:500-1000), IHC-P(1:200-400) |