15 Lipoxygenase 1 Polyclonal Antibody, ALEXA FLUOR¨ 555 Conjugated


15 Lipoxygenase 1 Polyclonal Antibody, ALEXA FLUOR¨ 555 Conjugated

  • Size: 100ul
  • Application: FCM, IF(IHC-P), IF(IHC-F), IF(ICC)
  • Reactivity: Human, Mouse, Rat
  • Predicted Reactivity: Cow, Pig

  • Datasheet      Tech Support


Catalog# bs-6505R-A555

Size:100ul Datasheet


 SizePrice
 100ul ₹ 52662

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PRODUCT DETAILS






SPECIFICATIONS

PRODUCT NAME

15 Lipoxygenase 1 Polyclonal Antibody, ALEXA FLUOR¨ 555 Conjugated

CONJUGATION

ALEXA FLUOR¨ 555

HOST

Rabbit

SOURCE

KLH conjugated synthetic peptide derived from human ALOX15/15 Lipoxygenase 1

IMMUNOGEN RANGE

581-662/662

CLONALITY

Polyclonal

ISOTYPE

IgG

CONCENTRATION

1ug/ul

PURIFICATION

Purified by Protein A.

STORAGE BUFFER

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

STORAGE CONDITION

Store at 4°C for 12 months.


TARGET

GENE ID

246

SUBCELLULAR LOCATION

Cytoplasm

SYNONYMS

12-LOX; 15LOX-1; 15-LOX-1; Arachidonate 15-lipoxygenase; 15-LOX; 12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate omega-6 lipoxygenase; ALOX15; LOG15

BACKGROUND

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

APPLICATION DILUTION

FCM(1:20-100), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)












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