PRODUCT NAME

Ado-trastuzumab emtansine Biosimilar - Research Grade

SPECIES REACTIVITY

Human

HOST

Humanized

SPECIFICITY

Detects human HER2. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Ado-trastuzumab emtansine. This product is for research use only.

PURIFICATION METHOD

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

ANTIGEN DISTRIBUTION

IMMUNOGEN

CONCENTRATION

FORMULATION

Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.

PURITY

>95% by SDS-PAGE and HPLC

ENDOTOXIN

≤ 0.75 EU/mg as determined by the LAL method

AGGRIGATION

STORAGE CONDITION

Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

TARGET

HER2

CLONE

SYNONYMS

BACKGROUND

Ado-trastuzumab emtansine is a HER2-targeted antibody-drug conjugate which contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug DM1 via the stable thioether linker MCC. Trastuzumab is produced by Chinese hamster ovary cells, and DM1-MCC are produced by chemical synthesis. Ado-trastuzumab emtansine contains an average of 3.5 DM1 molecules per antibody.

UNIPROT

PATHOGEN TEST

APPLICATIONS

APPLICATION NOTES

USAGE

Products are for research use only. Not for use in diagnostic or therapeutic procedures.