Eculizumab Biosimilar – Research Grade
- Sizes: 0.1mg, 5mg, 10mg, 20mg, 50mg
- Category: ichorbio, Low endotoxin, biosimilar antibody
- Target: Complement protein C5
- Clone:
- Host: Humanized
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PRODUCT DETAILS
SPECIFICATIONS |
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PRODUCT NAME |
Eculizumab Biosimilar - Research Grade |
SPECIES REACTIVITY |
Human |
HOST |
Humanized |
SPECIFICITY |
Detects human Complement protein C5. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Eculizumab. This product is for research use only. |
PURIFICATION METHOD |
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. |
ANTIGEN DISTRIBUTION |
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IMMUNOGEN |
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CONCENTRATION |
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FORMULATION |
Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free. |
PURITY |
>95% by SDS-PAGE and HPLC |
ENDOTOXIN |
≤ 0.75 EU/mg as determined by the LAL method |
AGGRIGATION |
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STORAGE CONDITION |
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles. |
TARGET |
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TARGET |
Complement protein C5 |
CLONE |
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SYNONYMS |
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BACKGROUND |
Eculizumab biosimilar is a recombinant humanized monoclonal IgG2/4κ antibody produced by Chinese hamster ovary cell culture and purified by standard bioprocess technology. Eculizumab biosimilar contains human constant regions from human IgG2 sequences and human IgG4 sequences and murine complementarity-determining regions grafted onto the human framework light- and heavy-chain variable regions. Eculizumab biosimilar is composed of two 448 amino acid heavy chains and two 214 amino acid light chains and has a molecular weight of approximately 148 kDa. |
UNIPROT |
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PATHOGEN TEST |
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APPLICATIONS |
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APPLICATION NOTES |
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USAGE |
Products are for research use only. Not for use in diagnostic or therapeutic procedures. |